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What are IT general controls (ITGCs) and why do they matter?

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Answer

ITGCs are controls over the IT environment that support reliable functioning of application controls—covering access security, change management, program development, and computer operations. If ITGCs are weak (e.g., poor access controls), automated application controls and system-generated data can't be relied upon, increasing risk and required substantive work.
Real-world example Weak access controls mean the auditor can't rely on the system's automated three-way match, so more substantive testing is needed.

Common follow-ups: What areas do ITGCs cover? | How do weak ITGCs affect application controls?